Friday, May 31, 2013

UPDATE: National Weather Service says Onawa storm probably not ...

ONAWA, Iowa (KTIV) -

Storms, packing winds with gusts over 80?per hour,?rolled through western Iowa,?Wednesday night.

From tree branches, to bricks, there was?a lot to clean up in the town of Onawa Thursday. When daylight came, the damage in Onawa was even more evident.

The storm, according to the National Weather Service came without warning, something that doesn't often happen these days.

Folks in Onawa, Iowa are cleaning up following Wednesday evening's storm, after they say something tore through the middle of town. "I opened up my screen door on the patio and no sooner than I opened it up and I literally stepped out one foot and felt my door get ripped off the house and fly in the wind," said Daniel King of Onawa, Iowa.

Some residents are convinced that it was a tornado.

James Davis, says surveillance video he captured shows a swirling motion moving down 10th street.

The National Weather Service blames 80 plus mile per hour winds on an intense downburst, which occurred without warning. "Downburst winds are very violent, and as they're slamming into the ground, absolutely there can be turbulence and rotation and swirling," said Jim Meyer, National Weather Service Meteorologist-In-Charge.

It left behind quite the mess.

Steve Gossage says the high winds took off an overhang at this Knoepfler Chevrolet building, crushing two cars beneath it. He says no one was inside. "The back door apparently was blown or sucked in. I had two garage doors back there. They were sucked in, and we don't know if the wind came through and blew it off or if it blew off and sucked the stuff in, we just don't know," said Steve Gossage, building owner.

Now he'll focus on rebuilding, while others offer a reminder that when push comes to shove, it's all about taking action. "You don't pass-go. You don't look at your TV. You don't gather up radio. You don't have time to go get money or anything. Sometimes, you literally have time just to run and get to shelter," said King.

The Onawa Police Department says that strong winds knocked out stop lights and even overturned a camper.

The National Weather Service does not plan on sending a survey team to the town to evaluate the damage.

Source: http://www.ktiv.com/story/22462670/2013/05/30/update-national-weather-service-says-onawa-storm-probably-not-tornadic

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Adult stem cells could hold key to cure type 1 diabetes

May 29, 2013 ? Millions of people with type 1 diabetes depend on daily insulin injections to survive. They would die without the shots because their immune system attacks the very insulin-producing cells it was designed to protect. Now, a University of Missouri scientist has discovered that this attack causes more damage than scientists realized. The revelation is leading to a potential cure that combines adult stem cells with a promising new drug.

The discovery is reported in the current online issue of Diabetes, the American Diabetes Association's flagship research publication. Habib Zaghouani, PhD, J. Lavenia Edwards Chair in Pediatrics, leads the research with his team at the MU School of Medicine.

"We discovered that type 1 diabetes destroys not only insulin-producing cells but also blood vessels that support them," Zaghouani said. "When we realized how important the blood vessels were to insulin production, we developed a cure that combines a drug we created with adult stem cells from bone marrow. The drug stops the immune system attack, and the stem cells generate new blood vessels that help insulin-producing cells to multiply and thrive."

Surrounded by an army of students and a colony of mice, Zaghouani has spent the past 12 years in his lab at MU studying autoimmune diseases like type 1 diabetes. Often called juvenile diabetes, the disease can lead to numerous complications, including cardiovascular disease, kidney damage, nerve damage, osteoporosis and blindness.

Type 1 diabetes attacks the pancreas. The organ, which is about the size of a hand and located in the abdomen, houses cell clusters called islets. Islets contain beta cells that make insulin, which controls blood sugar levels. In people with type 1 diabetes, beta cells no longer make insulin because the body's immune system has attacked and destroyed them.

When the immune system strikes the beta cells, the attack causes collateral damage to capillaries that carry blood to and from the islets. The damage done to the tiny blood vessels led Zaghouani on a new path toward a cure.

In previous studies, Zaghouani and his team developed a drug against type 1 diabetes called Ig-GAD2. They found that treatment with the drug stopped the immune system from attacking beta cells, but too few beta cells survived the attack to reverse the disease. In his latest study, Zaghouani used Ig-GAD2 and then injected adult stem cells from bone marrow into the pancreas in the hope that the stem cells would evolve into beta cells.

"The combination of Ig-GAD2 and bone marrow cells did result in production of new beta cells, but not in the way we expected," Zaghouani said. "We thought the bone marrow cells would evolve directly into beta cells. Instead, the bone marrow cells led to growth of new blood vessels, and it was the blood vessels that facilitated reproduction of new beta cells. In other words, we discovered that to cure type 1 diabetes, we need to repair the blood vessels that allow the subject's beta cells to grow and distribute insulin throughout the body."

Zaghouani is pursuing a patent for his promising treatment and hopes to translate his discovery from use in mice to humans. He is continuing his research with funding from the National Institutes of Health and MU.

"This is extremely exciting for our research team," he said. "Our discovery about the importance of restoring blood vessels has the potential to be applied not only to type 1 diabetes but also a number of other autoimmune diseases."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/9LLsiAZyDS4/130529154426.htm

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Thursday, May 30, 2013

Duracell Powermat PowerSnap Kit (for iPhone 5)


For everything the Apple iPhone 5 does well, the omission of future-tech like NFC or wireless charging remains a point of contention for many. The Duracell Powermat PowerSnap Kit ($99.99 list) addresses the latter, bringing wireless charging to the iPhone 5 via Duracell's established inductive charging system. It's the same tech behind the 24-Hour Power System?for the iPhone 4, but the PowerSnap Kit introduces a new design to mesh with Apple's new Lightning Connector, as well as a snap-on battery pack that turns it into one of the few battery-case solutions available for the iPhone 5. The kit faces the same problem that previous Duracell efforts faced?namely widespread adoption?and the new case is a bit too flimsy for my taste. If you think wireless charging is just too cool to pass up, though, the PowerSnap Kit is your best bet.

Design and Features
The kit consists of two pieces: a snap on AccessCase and a removable SnapBattery. The former is a thin and light plastic frame that adds wireless charging capability to the iPhone 5. The latter is a battery pack that attaches to the case for on-the-go power. The AccessCase breaks apart into two pieces; the top portion is nearly indistinguishable from your typical plastic snap-on case, while the bottom piece houses the Lightning Connector and hole for the 3.5mm headphone jack. Unlike battery cases like the Mophie Juice Pack Helium, Duracell left the space around the Lightning Connector empty. It definitely helps keep things thin and light, but it also leaves the case feeling unnecessarily fragile. The bottom portion also snaps in and out incredibly easy, which is nice for installation, but entirely disconcerting for security?it feels like it could break off with just a light drop, and the entire assembly has a bit too much wiggle to it. ?

Inline

The SnapBattery slides and snaps into place on the back of the AccessCase, holding itself in place with one tab at the top and two and the bottom. Together, the PowerSnap Kit feels far sturdier, but it's also a good deal bulkier at 5.36 by 2.41 by 1.15 inches (HWD) and 4 ounces. The Juice Pack Helium is considerably sleeker at 0.59-inch thick and 2.4 ounces.?On the back of the SnapBattery are four LED indicators and a Power button to control the flow of juice from the battery to the iPhone. Also on the SnapBattery is a spring-loaded door that covers a micro USB port for charging both the battery and iPhone when connected.

Performance and Conclusions
Charging works exactly like the 24-Hour Power System and older Powermat devices?simply place the SnapBattery or the AccessCase-clad iPhone 5 down on a Duracell Powermat to charge. The magnetic attraction helps guide the accessories into place and a pleasant chime confirms charging. You can charge the two pieces separately, or together with the SnapBattery attached to the AccessCase. Syncing must be done wirelessly, but that's also true of battery cases like the aforementioned Juice Pack Helium. Also keep in mind, you'll have to supply your own Duracell Powermat accessory, which starts at $34.99 for one device and goes up to $69.99 for three devices.

With the SnapBattery attached, the PowerSnap Kit is essentially a battery case for the iPhone 5, so we tested it as such using our standard battery rundown test. The PowerSnap Kit was able to add 5 hours of talk time over LTE to our AT&T iPhone 5, which alone lasted 8 hours, 40 minutes. The Juice Pack Helium added 6 hours, 20 minutes on the same test. As a battery case, the PowerSnap Kit is decent, but provides less power than dedicated cases in a significantly bulkier package.?

I have to admit wireless charging is pretty cool, but until there's a universal standard and widespread adoption, it's just not convenient enough to be your daily driver. Duracell is facing an uphill battle now as the Qi charging standard is being adopted by a variety of players, including HTC, Nokia, and Google itself with the Nexus 4. If you go the Duracell Powermat route, you'll have to invest in a good deal of accessories to make it really worthwhile. Neither has truly stablished dominance in the wireless charging realm yet, but you should keep in mind that if Duracell's standard doesn't gain more traction, you'll be left with a useless set of accessories once you upgrade your device. For some, that will be worth it for wireless charging, but for most it will be a novelty that loses its luster after that initial wonder wears off.?

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/KpcZ1O-bmw0/0,2817,2419282,00.asp

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With drones everywhere, what's private?

UK police officers use a remote control drone fitted with a TV camera to help combat potential??ATLANTA?Earlier this month, a woman in the Capitol Hill neighborhood of Seattle noticed a small camera-equipped drone buzzing around outside the third-floor window of her home. She sent her husband out to tell the man operating the small aircraft by remote control to leave, but he insisted that it was legal for him to fly above their property.

?We are extremely concerned, as he could very easily be a criminal who plans to break into our house or a peeping-tom,? the woman complained in a note to a local blog.

So was the drone operator right when he insisted that it was legal for him to fly above this woman?s yard?

The question doesn?t have an easy answer, and it?s one that some drone researchers gathered this week in Atlanta for an international conference on unmanned aircraft are grappling with.

Paul Voss, an engineer at Smith College who entered the drone field through his work developing the world?s smallest altitude-controlled meteorological balloons, gave a talk at the conference Wednesday titled ?The Case for Protecting Privacy and Property Rights in the Lowermost Reaches of the Atmosphere.? He argued that the drone community should be proactive in addressing privacy concerns now, before the number of drones in flight skyrockets when regulations are eased in the next few years.

At the beginning of his talk, Voss showed a photo of a drone hovering outside the second-floor window of a home, and asked the class, ?How many of you think this is public airspace?? Only one person raised his hand.

Voss thinks that one student is probably right, though it's a legal gray area. The Supreme Court ruled in 1946 that the air above the minimum safe altitude of flight ?is a public highway? and not subject to trespassing laws. The ruling reversed a lower court?s judgment in favor of a chicken farmer who lost 150 chickens due to fighter planes flying less than 100 feet over his roof on their way to a local airbase. (The chickens were so scared by the thunderous noise that they threw themselves against the wall and killed themselves.)

The court did, however, say that homeowners should have ?exclusive control of the immediate reaches of the enveloping atmosphere? so that they can build homes, plant trees and erect fences, for example. It?s unclear how many feet in the air, exactly, that extends to, as Justice William O. Douglas did not go into detail in the opinion.

That?s been the court?s final word, and the ruling suggests that drones can fly quite close above people?s property and be on safe legal ground.

But the bigger threat to privacy is less likely to come from nosy neighbors with tiny camera-equipped model aircraft than from well-funded law enforcement agencies or businesses that can afford to launch sophisticated drones with high-power cameras.

Brandon Stark, a drone researcher at the University of California, Merced, told the scientists at a workshop Tuesday that smaller drones are not yet sophisticated enough to merit privacy advocates? concerns about spying. ?If you?re flying [a small drone] 100 feet into the sky, you?re lucky to see a tree. Actually spying on people is fairly difficult and fairly expensive,? he said.

Those who can actually afford the most powerful drones are likely to be law enforcement agencies with grants from the federal government, or businesses hoping to turn a profit. That could mean a big expansion in the ability of police to gather evidence and detect crime. A 1989 Supreme Court ruling held that police can use images from manned aircraft to aid their investigations without first obtaining a warrant. In that case, a sheriff discovered a man was growing marijuana in a greenhouse by sending a helicopter to fly overhead at just 400 feet without first having to prove to a judge he had good reason to search his home.

Privacy advocates are concerned that drones will take police power to another level, since drones could in theory hover around an area continuously, surveying from the skies and reporting any suspicious activity.

Drones are tightly regulated right now by the Federal Aviation Association, which prohibits people from using them in any commercial endeavor and requires public institutions to apply for authorization to use them. (Hobbyists can fly small drones as long as they're within sight at all times and stay under 400 feet.)

But that?s all expected to change in 2015, when the agency is required by Congress to open up the skies to commercial uses of drones and attempt to integrate unmanned and manned aircraft. The agency estimates that nearly 10,000 new drones will be in flight in just the first few years after the commercial ban is lifted.

It?s unclear whether the FAA will delve into any of the privacy issues when it issues its regulations on unmanned aircraft. Ted Wierzbanowski, a retired Air Force colonel who chaired a committee that made recommendations to the FAA on how to regulate small drones, said he believes the FAA should focus on safety, not privacy, in its regulations. ?Someone else in the government should have to worry about privacy issues. Who that is, I don?t know,? he said.

Amie Stepanovich, director of the Domestic Surveillance Project at the Electronic Privacy Information Center, said her organization is petitioning the FAA to require a publicly accessible registry of drones?where they?re flying, who is flying them, and what sort of data they are collecting?so that concerned citizens can look up their home and see who might be watching it.

Congress, meanwhile, has shown some willingness to step in, with some Republican representatives working on a bill that would limit the police?s ability to use drones without first obtaining a warrant.

Another possibility is that much of the privacy battles will be fought at the local level, with each state developing standards for how law enforcement can use drones and how to mediate disputes among neighbors who use drones. Dozens of states have introduced legislation just this year to limit the ways in which police departments can use drones.

Source: http://news.yahoo.com/blogs/ticket/privacy-looming-issue-drone-regulation-loosens-111425343.html

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Wednesday, May 29, 2013

Amazon announces new 'Login with Amazon' service for apps, games and websites (video)

Amazon announces new 'Login with Amazon' service for apps, games and websites video

In an effort to reducing keyboard wear-and-tear, Amazon is opening up its own login service to both app developers and websites. Login With Amazon taps into your account credentials to login, with the ability to even share parts of your profile through apps, games and sites. It uses the retailer's existing trusted sign-in security and has already been tested on both Zappos and Woot, with both trials apparently noting "significant" pickup from customers. The service is free to use and if you're thinking of adding it to your own site (and tapping into those 200 million registered Amazon users), you can find all the technical details at the source -- or a gentler explanation in a video after the break.

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Source: Amazon (1), (Login with Amazon)

Source: http://www.engadget.com/2013/05/29/amazon-login-service-password/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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The Leprechaun Reboot Has a Director

Looks like we can add ?Hornswoggle? to the list of lucky charms: After the WWE star signed on to play the title role in a reboot of horror series ?Leprechaun,? the film has finally found its director.

The Wrap reports that visual effects specialist Zach Lipovsky will helm the long-awaited feature, based on the 1993 flick starring Warwick Davis and Jennifer Anniston. Lipovsky, who got his big break when he won the short-lived Steven Spielberg-Mark Burnett reality series ?On the Lot,? has directed numerous short films and TV movies, but never a theatrical feature.

?Leprechaun,? which toed the line between horror and comedy and spawned several sequels, focused on an evil leprechaun searching for his pot of gold and dodging four-leaf clovers. Producers of the reboot have been mum about what screenwriter Harris Wilkinson?s script entails, preferring the franchise?s new direction remain a mystery ? though Hornswoggle?s WWE affiliation (and Irish in-the-ring persona) ensures that the new villain should be able to kick some gold-stealing butt.

The film is a joint venture between Lionsgate and WWE studios. No word yet on production or release dates, but here?s hoping Hornswoggle?s involvement keeps the tongue-in-cheek spirit of the original intact.

[via The Wrap]

Earlier on Moviefone:

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Source: http://www.rottentomatoes.com/m/1927547/news/1927547/

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Canada's Flaherty: No 'doom and gloom' in Canada housing market

Canada's Finance Minister Jim Flaherty arrives for the Global Investment Conference 2013 in London

Canada's Finance Minister Jim Flaherty arrives for the Global Investment Conference 2013 in London

OTTAWA (Reuters) - There's no "doom and gloom" in Canada's housing market, Finance Minister Jim Flaherty said on Monday, suggesting he sees a soft landing rather than a U.S.-style collapse as demand and prices cool.

"When I look at the housing market, I'm looking for the 'doom and gloom.' I don't see the 'doom and gloom,'" Flaherty told reporters, referring to market players who predict Canada has a housing bubble on the verge of bursting.

"I see some moderation in demand. This is a good thing," Flaherty said.

Canada's housing market was red hot in the years following the 2008-09 recession. But it began cooling in the middle of 2012 in the wake of government moves to tighten mortgage lending rules.

Flaherty wished "bad luck" to any big U.S. hedge funds betting short-selling the Canadian market in the belief the housing market will crash, in hopes of making a profit.

Most economists in Canada are forecasting a gradual downturn in housing but there are a few outliers warning of a pending disaster given the record-high debt load of Canadian households at a time when interest rates can only go up.

(Reporting by Louise Egan; Editing by Nick Zieminski)

Source: http://money.ca.msn.com/investing/news/breaking-news/canadas-flaherty-no-doom-and-gloom-in-canada-housing-market

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Stop Credit Card Debt

First thing to do is obtain one's credit report. One may think they are aware of all their liabilities, but these in depth financial reports will show everything that is owed and perhaps reveal mistakes that need to be cleared up. It is very important that credit card accounts are paid before it goes to collection or the person has to file for bankruptcy.

The second thing to do to stop credit card debts is to observe past spending habits. What is the card used for? Why can't the balance be paid off each month? Most people use this borrowing tool on a daily basis instead of check cards, cash, or checks. If one records spending habits faithfully, this may not be a problem, but if not keeping track of what is spent, they could be in a world of trouble. Attempt to eliminate such obligations one month at a time by only using cash and check. Of course, continue to pay the account payments, but use this method for several months and see how spending habits change and how financial woes decrease.

Third, now that one understands where spending habits need to be changed and how easily it can be to stop credit card debts, create some goals, rules, and rewards. For instance, if one can stop credit card debt by paying double on their account payment each month, then perhaps they can consider planning a nice visit with an old friend. The rewards should not cost a lot of money (if any at all) because that would defeat the purpose. Tell close friends of the plan to stop credit card debts. Having an accountability partner will be a good support system and might even encourage that person to excessive spending of their own.

Having a plan to eliminate continued borrowing and telling friends and maybe even family about the plan to stop credit card debt will help one rest easier knowing that the end of debt is in sight. It may be a long time from now, but at least they are working in the right direction. There are many professional services available that can help create a plan without consolidating or filing for bankruptcy. Remember, the best way to stop credit card debt is to create a plan that works for each individual and stick to it.

Source: http://www.christianet.com/debt/stopcreditcarddebts.htm

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Bollywood star Shah Rukh Khan undergoes surgery

NEW DELHI (AP) ? Bollywood megastar Shah Rukh Khan has undergone surgery for a shoulder injury suffered while doing stunts for his new movie, "Chennai Express."

Sanjay Desai, his doctor, said Khan's surgery in a Mumbai hospital Tuesday was successful but he will need to rest for two months.

He refused to use body doubles and performed his own stunts for the movie, the Press Trust of India news agency said. The 47-year-old is expected to leave the hospital this weekend.

Khan is one of Bollywood's biggest stars in India. He has acted in more than 70 films in a career spanning more than two decades.

Source: http://news.yahoo.com/bollywood-star-shah-rukh-khan-undergoes-surgery-064240301.html

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Tuesday, May 28, 2013

Military exemptions threaten Israeli coalition

JERUSALEM (AP) ? The leader of Israel's second largest party warned Monday that Prime Minister Benjamin Netanyahu's ruling coalition could collapse if it fails to reform the military draft system and end exemptions for ultra-Orthodox Jewish seminary students.

Finance Minister Yair Lapid made the threat after a committee meeting tasked with changing the draft rules ended without results. Lapid's party surged in January's parliamentary election by vowing to force the ultra-Orthodox to "share the burden" of military service.

Military service is compulsory in Israel from age 18, but thousands of ultra-Orthodox Jews get exemptions each year to pursue religious studies. The ultra-Orthodox insist military service would compromise their strict religious lifestyle, while Israelis who serve in the military charge that the system is unfair.

"Whoever thinks that Yesh Atid will fold on the issue of sharing the burden simply doesn't know us or understand us," Lapid said at a meeting of his party. "There will be an equal sharing of the burden, or this government will fall apart," he said.

His comments appeared to be an opening salvo in what will likely be a lengthy debate.

Prime Minister Benjamin Netanyahu has said there will be many "headlines and crises" until all the issues are ironed out. But he said that in the end, solutions will be found and the law will be passed.

In the early days of the Jewish state a small core of a few hundred ultra-Orthodox Jewish scholars were granted draft exemptions, partially in order to encourage scholarship after the great European schools of Jewish thought were destroyed by the Nazis and their collaborators during World War II.

Over the years the numbers of exemptions mushroomed into tens of thousands, and the legitimacy of the scholarly pursuits of so many young people came into question.

A committee tasked with composing draft reforms met late into the night Sunday but ended in acrimony over disputes about penalties for draft evaders and other clauses.

Under the new proposed system, seminary students would be allowed to continue their studies and would not be required to perform military service until age 21. That could signal a relatively easy term of service, since older soldiers typically serve for shorter periods of time and usually not in combat units.

The system under consideration would not go into effect for three years, meaning that thousands of seminary students who are studying now would not have to serve.

Source: http://news.yahoo.com/military-exemptions-threaten-israeli-coalition-135508650.html

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White House security adviser calls for deeper China military ties

BEIJING (Reuters) - The United States called for deeper military ties with China on Tuesday, including working closer together in areas like peacekeeping, fighting piracy and disaster relief, despite growing tensions between the two on a range of security issues.

White House National Security Adviser Tom Donilon made the remarks at a meeting with senior Chinese military leader Fan Changlong, two weeks ahead of a summit between the U.S. and Chinese presidents in California.

"An essential part of building a new model for relations between great powers is ensuring we have a healthy, stable and reliable military to military relationship," Donilon told Fan at the Chinese Defence Ministry, in brief comments before reporters.

He added the two countries should work to face "non-traditional security challenges" including peacekeeping, disaster relief and countering piracy.

Fan, the vice chair of China's powerful Central Military Commission, called for a "new type of major power relations".

Neither Donilon nor Fan mentioned the numerous sensitive areas Chinese President Xi Jinping and U.S. President Barack Obama are expected to discuss in June, including tensions on the Korean peninsula and a string of cyber attacks the United States has linked to China.

Donilon met Xi on Monday, during which Xi said Sino-U.S. relations were at "an important stage connecting the past and the future", according to China's official Xinhua news agency.

Neither side has given details about what will be discussed at the summit, set for June 7-8 at a sprawling California estate called Sunnylands, which lies southeast of Palm Springs.

While military relations between the world's two largest economies have thawed considerably in the last two years, deep suspicions and sticking points remain, including China's role in pushing North Korea to abandon its nuclear weapons program.

Fan and Xi both met with Choe Ryong-hae, a special envoy of North Korean leader Kim Jong-un, earlier this month. The U.S. will likely continue pressuring China to enforce international sanctions on Pyongyang.

(Reporting By Megha Rajagopalan; Editing by Michael Perry)

Source: http://news.yahoo.com/white-house-security-adviser-calls-deeper-china-military-042040645.html

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Syrian opposition shake-up falters ahead of peace conference

By Khaled Yacoub Oweis

ISTANBUL (Reuters) - A crisis in Syria's opposition deepened on Monday when liberals were offered only token representation, undermining international efforts to lend the Islamist-dominated alliance greater support.

To the dismay of envoys of Western and Arab nations monitoring four days of opposition talks in Istanbul, the 60-member Syrian National Coalition thwarted a deal to admit a liberal bloc headed by opposition campaigner Michel Kilo.

The failure to broaden the coalition, in which Qatar and a bloc largely influenced by the Muslim Brotherhood has been playing the driving role, could undermine Saudi Arabian support for the revolt and raise the specter of a rivalry among Gulf powers that could further weaken the opposition.

Its Western backers have pressured the Coalition to resolve its divisions and expand to include more liberals to counter domination by Islamists. The plan also had support from Saudi Arabia, which had been preparing to assume a bigger role in coalition politics and has been uneasy about the rise of Qatar's influence, coalition insiders said.

Its apparent failure to do so came hours before the European Union was scheduled at a meeting in Brussels to discuss lifting an arms embargo that could allow weapons to reach rebel fighters in Syria seeking to oust President Bashar al-Assad.

The disarray also threatens to strengthen Assad's hand ahead of a international peace conference backed by the United States and Russia, planned to be held in Geneva in the coming weeks.

U.S. Secretary of State John Kerry and Russian Foreign Minister Sergei Lavrov were due to meet in Paris on Monday to discuss that planned conference.

Kilo's group received an offer of only five seats - instead of the more than 20 it had been looking for - after a session in Turkey that stretched nearly to dawn, coalition sources said.

The move left the Coalition controlled by a faction loyal to Qatari-backed Secretary-General Mustafa al-Sabbagh, and a bloc largely influenced by the Muslim Brotherhood. That group led resistance to the rule of Assad's late father in the 1980s, when thousands of its members were tortured and executed.

"We were talking about 25 names as the basis for our negotiations, then there was agreement on 22 and then the number dropped to 20, then to 18, then to 15, then to five," Kilo said, addressing the Coalition.

"I do not think you have a desire to cooperate and hold our extended hand. ... We wish you all the best."

A member of the Kilo camp said his bloc would meet later to decide whether to withdraw from the opposition meeting, although he said the coalition may still make a better offer.

Coalition spokesman Khaled Saleh described the outcome as "democratic" but said the Coalition could discuss the expansion issue further.

SAUDI SIDELINED

With Lebanese Shi'ite guerrillas from Iranian-backed Hezbollah now openly fighting alongside government troops in Syria, Saudi Arabia is keen to play a greater role in backing the Sunni-led opposition, opposition sources have said.

Significant expansion of the 60-member Coalition would have diluted the influence of Qatar, the other main Arab player backing the revolt against Assad.

Coalition members who had campaigned for an organizational shake-up said the feeble offer to Kilo's bloc was an affront to Riyadh and would make Saudi Arabia balk at backing the opposition more forcefully.

"The only time the Saudis ask for something substantive from the opposition we turn them down," a coalition source said.

"Saudi Arabia before this meeting was on the verge of throwing its weight behind the revolt. It would have made sense for Qatar to take a role in line with its size and let Saudi Arabia take a lead role. Sabbagh, and apparently Qatar, got their way, but at what expense?"

Sabbagh, who has played a main role in channeling money for aid and military supplies into Syria, has been resisting a Saudi-supported plan to add members to the Coalition, opposition sources said.

"Sabbagh has been told by Qatar that the Saudis are brothers and he should compromise. But he is a Syrian first and he will put the interest of the national opposition above everything," an ally of Sabbagh in the Coalition said.

The Coalition's meeting in Istanbul has been extended by two days to discuss the Geneva conference and a new leadership, including the fate of provisional Prime Minister Ghassan Hitto, who has not been able to form a provisional government in exile since being appointed on March 19.

The Coalition has been rudderless since the resignation of Moaz AlKhatib, a cleric who had floated two initiatives for Assad to leave power peacefully.

(Editing by Nick Tattersall and Alastair Macdonald)

Source: http://news.yahoo.com/syrian-opposition-shake-falters-ahead-peace-conference-034903016.html

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Monday, May 27, 2013

Insight: The maverick challenging Spanish politics

By Fiona Ortiz and Elisabeth O'Leary

MADRID (Reuters) - Spain's rising political star is a 61-year-old former Socialist whose message of changing the system from within is drawing voters in despair at economic ruin and official corruption in the euro zone's fourth biggest economy.

Lacking the raucous anti-establishment appeal of Italy's Beppe Grillo and Greek leftist hero Alexis Tsipras, Rosa Diez relies on sharp debate to deliver her reform message to a country pushed to the brink by the euro zone debt crisis.

Diez split from the Socialist party six years ago and formed the centrist Union for Democracy and Progress, or UPyD.

Polls show she is Spain's most highly regarded politician at a time when a quarter of workers are out of a job and public disenchantment with the political class is rising, as is the caseload of judges investigating allegations of official graft.

Projections by Metroscopia polling firm show that if elections were held now, Diez's party could take as many as 30 seats in the 350 seat parliament, up from five at present.

The former Communists the United Left could quadruple its presence to 48 seats, perhaps forcing one of Spain's two main political forces, the socialists or the centre-right People's Party, to form a coalition government for the first time.

Although the bigger parties will expect to win back support during campaigning for the 2015 vote, the growing impact of smaller parties is bringing about a dramatic and permanent change in the political landscape.

"The two-party system has suffocated democracy and people know that. A huge majority of Spanish citizens want a radical change in the political system," Diez said in an interview with Reuters.

She cultivates a maverick image - an asymmetrical haircut and each fingernail painted a different color - but her politics are far from revolutionary. She defines herself as a social-liberal who endorses free-market economics.

SPANISH EXCEPTION

When Spain returned to democracy in the 1970s after Francisco Franco's dictatorship, the electoral system was set up to guarantee stability by limiting proportionality and favoring two major parties.

Over the past 36 years the People's Party - which currently has an absolute majority in parliament - and the Socialists carved up power and controlled everything from savings banks to the justice system. To pass laws they counted on votes from nationalist parties from the wealthy Basque and Catalan regions, which received extensive self-governing powers in return.

The challenge to that long-running status quo in Spain reflects political upheaval all over Europe, where populists and extremists have tapped into public rejection of austerity measures, immigration, recession and unemployment.

In Britain, a far-right campaign to leave the European Union has gained ground; comedian-turned-activist Grillo has became a major force in Italy; and in Greece radical leftists and ultra-nationalists are growing in influence.

The economic picture in Spain is among the bleakest after a construction boom turned to bust, draining the banks and pushing up corporate insolvencies. Unemployment is around 27 percent. Madrid sought 42 billion euros in international assistance last year to put the financial system on an even keel.

But while the rise of smaller parties has meant destabilizing fragmentation and shaky coalitions in countries such as Italy and Greece, in Spain the recent shadow of fascism means there is little appetite for extremism.

Here, the increased weight of alternative voices could be a sign of maturing democracy, some observers say.

"It's going to be very difficult for the two big parties to recover legitimacy. Governing will be more difficult in the future but I'm skeptical of an Italian scenario. Spaniards are wary of extremism," said Antonio Barroso, a London-based political analyst at Teneo Intelligence, an advisory firm.

Diez's father was imprisoned for his political beliefs under Franco and she says she was "nursed on politics."

After Franco died and Spain finally held elections - in 1977 - Diez said "it was only logical" for her to run for office. She has been in politics ever since.

Still, she has managed to paint herself as an outsider and draw support from both the left and the right for her pro-European views and centrist line. She defines herself as a social-liberal who endorses free-market economics, progressive individual liberties and a social safety net.

"I voted for her because she's very charismatic. She's daring and different and I thought she would break barriers and do different things. I was totally disappointed with the two main parties," said Jose Miguel Delgado, 47, an industrial technician.

RECKLESS BANKS

Diez has tapped into public outrage over the costly bailout for banks that loaned recklessly during the real-estate boom.

"She has a great nose for social change and is able to convert that into party ideology," says a political rival who has worked with her in parliament for many years.

Diez's party has brought a lawsuit against former board members of Bankia, a major Spanish bank that almost collapsed last year and received the biggest bailout in the country's history.

The rescue came just as the government was cutting spending on hospitals and schools and rising numbers of Spaniards were out of work, defaulting on their mortgages and losing their homes.

The People's Party (PP) has seen its support dwindle to some 29 percent from 45 percent in the last elections as Prime Minister Mariano Rajoy takes unpopular economic measures. His credibility was also damaged by allegations that high-level executives in his party channeled cash donations from business leaders to party leaders. A judge is investigating the charges.

PEOPLE'S HERO

Spaniards are turning not only to alternative political leaders like Diez and Lara. They are also increasingly involved with social movements.

A new hero to many is Ada Colau, 39, leader of an activist group called the Mortgage Victims Platform that helps jobless mortgage defaulters fight the banks. Last year 39,000 families left their homes because of mortgage problems. Of those almost 3,000 were forcibly evicted.

Barcelona-based Colau, frequently seen on television at protests outside banks, says a sign of the impact her group has had is that a director at one of Spain's biggest banks consulted with the Platform on an affordable housing proposal.

The Platform has an approval rating of 71 percent, according to a recent opinion poll, while politicians in general are the very lowest rated institution in all of Spain, with a disapproval rating of 93 percent.

The influence of the Platform has alarmed the PP government.

PP Secretary General Maria Dolores de Cospedal accused the Platform of demagoguery and said they should legitimize themselves by forming a political party, an idea Colau rejects.

"People stop me on the street and ask me to run for office," Colau told Reuters. "But if I did, the only thing I'd be able to do every now and again would be to have a tantrum in Parliament. I'd have much less influence than I have now."

LIMITED ROLE

Diez, meanwhile, enjoys a high profile due to her weekly show-downs with the prime minister in televised parliamentary debates. Spaniards gave Diez a grade of 3.96 in a survey this month by Metroscopia. Premier Rajoy got a grade of 2.44, while Socialist leader Alfredo Perez Rubalcaba got a 3.00, and no politician beat Diez.

While she's well-regarded now, she may find it hard to maintain a simultaneous role as rebel and political operator.

Critics say Diez's rise will be limited by her focus on returning powers to the central government that have been ceded to regional governments in Catalonia and Basque Country, and by a lack of detail in her economic policy.

Diez rejects the criticism, pointing to her initiatives to shut down public companies and unnecessary institutions, simplify employment contracts to make hiring and firing cheaper for corporations, and standardize business rules across Spain.

She does acknowledge it will be difficult for her party to break into the big time unless Spain reforms election laws that make it hard for minority parties to get representation anywhere except the largest cities, Madrid and Barcelona.

Experts are skeptical there is any political will to overhaul the electoral system and destroy the PP and Socialist power bases in local governments around the country.

"If you have a society in which most people are benefiting from protectionism or favours from the political system, it's very difficult to see how that same system is going to remove those," said Dr. Jonathan Hopkin, a politics expert at the London School of Economics.

One arena where the UPyD and the United Left can both shine is in European Parliamentary elections next year, where they are expected to gain significant numbers of seats because that vote is run on a strictly proportional basis.

(editing by Janet McBride)

Source: http://news.yahoo.com/insight-maverick-challenging-spanish-politics-060204043.html

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Sunday, May 26, 2013

Ethiopian marathon runner honors Boston victims

Runners who were unable to finish the Boston Marathon on April 15 because of the bombings cross the finish line on Boylston Street after the city allowed them to finish the last mile of the race in Boston, Saturday, May 25, 2013. (AP Photo/Winslow Townson)

Runners who were unable to finish the Boston Marathon on April 15 because of the bombings cross the finish line on Boylston Street after the city allowed them to finish the last mile of the race in Boston, Saturday, May 25, 2013. (AP Photo/Winslow Townson)

(AP) ? The winner of the men's race at the Boston Marathon says he is returning his winner's medal to honor the city and those killed and injured in the terrorist bombings near the finish line of one of the world's top running events.

Lelisa Desisa says sport should be a pleasure and never a battlefield. He made the announcement Sunday at a ceremony with U.S. Secretary of State John Kerry. Kerry also honored the woman's runner-up and the men's third place finisher. All three athletes are from Ethiopia.

The April 15 explosions killed three people and injured more than 260 others.

Kerry is in Ethiopia to mark the 50th anniversary of the African Union.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-05-26-Kerry-Boston%20Marathon/id-5547ea298165442cb37cd44fd3eed2af

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Kerry makes 1st official sub-Saharan Africa visit

ADDIS ABABA, Ethiopia (AP) ? Making his first official trip to sub-Saharan Africa, U.S. Secretary of State John Kerry on Saturday demanded that Nigeria respect human rights as it cracks down on Islamist extremists and pledged to work hard in the coming months to ease tensions between Sudan and South Sudan.

Kerry, attending the African Union's 50th anniversary, backed the Nigerian government's efforts to root out Boko Haram, an al-Qaida-linked radical sect. But he said there is no excuse for abuses by armed forces in Nigeria's long-neglected north, where President Goodluck Jonathan has declared emergency rule.

"We defend the right completely of the government of Nigeria to defend itself and to fight back against terrorists," Kerry said. He added, however, that he has raised his concerns with Nigerian officials to insist on the military "adhering to the highest standards and not itself engaging in atrocities."

"One person's atrocities do not excuse another's," said Kerry, who later made his case directly to Jonathan over lunch. "Revenge is not the motive. It's good governance, it's ridding yourself of a terrorist organization so that you can establish a standard of law that people can respect."

Amnesty International says Nigeria's military has committed "grave human rights violations" over the last three years, including executions and kidnappings. It is reporting continued wrongdoing, while Human Rights Watch says satellite images showed "massive destruction of civilian property" in a military raid last week.

Speaking to reporters alongside Ethiopian Foreign Minister Tedros Adhanom Ghebreyesus, Kerry also blamed Sudan's government for much of the tension along its volatile border with South Sudan. He says residents in the contested areas of Blue Nile and South Kordofan don't want to be subjected to strict Islamist rules.

Both areas border the new nation of South Sudan, which gained independence in 2011 under an agreement that ended decades of civil war. Many residents are sympathetic to the South, and both areas have experienced regular violence in recent years.

"There are very significant border challenges, but they're bigger than that," Kerry said. "You have people who for a long time have felt that they want their secular governance and their identity respected."

"They don't want independence; they are not trying to break away from Sudan," he said. But he said the response from Sudan's government has been to "press on them through authoritarian means and violence an adherence to a standard that they simply don't want to accept with respect to Islamism."

"That's the fundamental clash," Kerry said.

He acknowledged, however, the North's concerns that the South is fueling rebels in the areas and said the U.S. would try to work with Ethiopia and other international partners to ease tensions. He said he'd soon appoint a new American envoy to both countries.

Kerry met Sudan's foreign minister later Saturday.

His meetings in Ethiopia's capital also included the U.N. and African Union chiefs and Egyptian President Mohammed Morsi.

Source: http://news.yahoo.com/kerry-makes-1st-official-sub-saharan-africa-visit-181521622.html

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Wednesday, May 22, 2013

Kerry visits Oman for arms deal signing, talks on Syria, Mideast

By Arshad Mohammed

SHANNON, Ireland (Reuters) - U.S. Secretary of State John Kerry flies to Oman on Tuesday for Raytheon Co's signing of an estimated $2.1 billion arms deal and to consult on Syria and Iran, U.S. officials said.

Oman is expected to sign a letter of intent to purchase a ground-based air defense system that would help protect against cruise missile or drone attacks, a senior U.S. State Department official told reporters aboard Kerry's plane.

The official, who spoke on condition of anonymity, said the terms were still being negotiated and the final value of the sale could change, adding that it was not clear whether Kerry would attend the signing expected on Tuesday or Wednesday. Raytheon spokesman Jonathan Kasle had no immediate comment.

Raytheon Chief Executive Bill Swanson told an earnings call last month that the company was making "considerable progress" on a number of foreign arms sales, including a deal to sell a ground-based air defense system to Oman.

Raytheon generates more of its revenues overseas than any other large U.S. weapons maker. It has forecast a 20-percent increase in foreign bookings in 2013.

Oman sits opposite Iran on the Strait of Hormuz, through which some 40 percent of the world's sea-borne oil passes, and is a U.S.-allied Gulf Arab State while also maintaining good relations with the Shi'ite-ruled Islamic republic.

Kerry's visit is the first stop on a week-long trip that will take him to Amman for talks on bringing Syria's warring parties to a peace conference and to Jerusalem and Ramallah to discuss reviving Israeli-Palestinian peace negotiations.

Both issues are expected to come up when Kerry meets Oman's Sultan Qaboos bin Said, the Arab world's longest-serving ruler, on Tuesday, said the officials, who spoke to reporters while Kerry flew to Ireland for refueling before heading to Oman.

"It's basically a chance to do a signals check with an important ally," said a second senior State Department official. "Oman is not a key player on Syria but, as an important player in the Gulf, I think it will be good to hear the sultan's views on the situation in the region writ large."

More than 80,000 people are believed to have died in Syria's civil war, which began with peaceful protests against President Bashar al-Assad's rule more than two years ago as popular uprisings swept long-time authoritarian rules from power in Tunisia, Egypt and Libya.

It has since become an all-out fight between opposition fighters who have Arab and some Western backing and government forces that are supported by Iran and Lebanese Hezbollah and that benefit from diplomatic support and arms sales from Russia.

Rebel and government forces engaged in their fiercest fighting this year in the rebel stronghold of Qusair, Syrian activists said, saying about 30 Lebanese Hezbollah fighters and 20 Syrian soldiers and militiamen loyal to Assad have been killed in the clashes.

The reported Hezbollah losses reflect the extent to which the Syrian conflict is turning into a proxy war between Shi'ite Iran and U.S.-aligned Gulf Arab states such as Saudi Arabia and Qatar, which back Assad's mostly Sunni foes.

Kerry on Wednesday will meet in Amman with senior officials from mostly Western and Arab states that are backing the Syrian opposition to discuss how to bring both sides to the negotiating table.

The United States and Russia announced two weeks ago that they would try to bring the two sides together - possibly in June in Geneva - for a peace conference that would choose a transitional government.

(Reporting by Arshad Mohammed; Additional reporting by Andrea Shalal-Esa; Editing by Eric Beech, Bill Trott and Paul Simao)

Source: http://news.yahoo.com/raytheon-sign-2-1-billion-arms-sale-oman-000753577.html

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Monday, May 20, 2013

A tour of the Jolla phone with company co-founder Marc Dillon (video)

A tour of the Jolla phone with software head Marc Dillon video

Say hello to the Jolla Phone. Pre-orders for the world's first Sailfish OS device started today and we've called into Helsinki to get the whole story from Jolla's co-founder and software head Marc Dillon. While we know there's a 4.5-inch "high definition" screen (resolution TBC), dual-core processor and 8-megapixel camera, we were kept at arms length during our meeting with an early prototype. So, unfortunately, our full hands-on treatment will have to wait until later today. For now, Marc takes us through the thinking behind the hardware -- and what the notion of the "other half" really means -- right after the break.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/7QdOwQJhCuM/

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Jury gets first glimpse of defense in Jackson case

File - In this March 5, 2009 file photo, US singer Michael Jackson announces at a press conference that he is set to play ten live concerts at the London O2 Arena in July 2009. Jurors hearing Katherine Jackson?s lawsuit against AEG Live heard from a pair of defense witnesses who gave varying assessments of Jackson?s health as he rehearsed for the ?This Is It? show. The testimony in a Los Angeles courtroom by choreographers Stacy Walker and Travis Payne on May 13-14, 2013, was the only evidence in the trial?s third week that focused on the pop superstar. (AP Photo/Joel Ryan, File)

File - In this March 5, 2009 file photo, US singer Michael Jackson announces at a press conference that he is set to play ten live concerts at the London O2 Arena in July 2009. Jurors hearing Katherine Jackson?s lawsuit against AEG Live heard from a pair of defense witnesses who gave varying assessments of Jackson?s health as he rehearsed for the ?This Is It? show. The testimony in a Los Angeles courtroom by choreographers Stacy Walker and Travis Payne on May 13-14, 2013, was the only evidence in the trial?s third week that focused on the pop superstar. (AP Photo/Joel Ryan, File)

FILE - In this June 23, 2009 handout photo provided by AEG, pop star Michael Jackson rehearses at the Staples Center in Los Angeles. Jurors hearing Katherine Jackson?s lawsuit against AEG Live heard from a pair of defense witnesses who gave varying assessments of Jackson?s health as he rehearsed for the ?This Is It? show. The testimony by choreographers Stacy Walker and Travis Payne in a Los Angeles courtroom on May 13-14, 2013, was the only evidence in the trial?s third week that focused on the pop superstar. (AP Photo/ Kevin Mazur, AEG/Getty Images, File)

(AP) ? A look at key moments this past week in the wrongful death trial in Los Angeles between Michael Jackson's mother, Katherine Jackson, and concert giant AEG Live LLC, and what is expected at court in the week ahead:

THE CASE

Jackson's mother wants a jury to determine that the promoter of Jackson's planned comeback concerts didn't properly investigate Dr. Conrad Murray, who a criminal jury convicted of involuntary manslaughter for Jackson's June 2009 death. AEG's attorney says the case is about personal choice, namely Jackson's decision to have Murray serve as his doctor and give him doses of a powerful anesthetic as a sleep aid. Millions, possibly billions, of dollars are at stake.

WHAT HAPPENED

? Jurors heard from AEG Live's first two witnesses, a pair of choreographers who worked on Jackson's ill-fated "This Is It" shows. Stacy Walker told the panel she never saw any signs Jackson was impaired or ill during rehearsals. Her colleague Travis Payne, who rehearsed one-on-one with Jackson, acknowledged he couldn't say how many times the pair actually rehearsed and said he was concerned the singer was under the influence of prescription medications in the weeks before his death.

? An AEG accounting executive testified about the budget for "This Is It," which was planning on paying Murray up to $1.5 million for the first few months of the shows. The former cardiologist was never paid because Jackson died before signing his contract.

WHAT THE JURY SAW

? Payne shift from a composed, sometimes-smiling witness to one who fought back tears toward the end of his day-and-a-half of testimony. His devotion to Jackson was evident from his wardrobe, which included a black blazer with an emblem stitched onto each sleeve containing the letters "MJ" and golden wings.

? Lots of courthouse hallways and downtown Los Angeles. Friday's session featured a four-hour lunch break due to witness availability issues. The trial's third week featured only three days of live testimony and the jury was kept waiting or sent out of the room numerous times while attorneys argued legal issues.

QUOTABLE MOMENTS

? "Sometimes in rehearsal, Michael would appear just a little loopy," Payne said of Jackson's demeanor after visiting his longtime dermatologist Dr. Arnold Klein, who is not a party to the case.

? "I just never in a million years thought he would leave us, or pass away," choreographer Stacy Walker said of Jackson. Walker testified for AEG and said she never saw signs Jackson was under the influence of medications or was ill.

OUTSIDE THE COURTROOM

? A state attorney urged a court to reject an appeal by Jackson's former doctor, Conrad Murray, stating there were no legal errors by a trial judge and the physician's own attorneys failed to raise issues at the appropriate time. Murray has shown no remorse for playing "Russian roulette" with Jackson's life.

WHAT'S NEXT

? A corporate attorney for AEG Live will testify, reflecting a shift in the trial focus away from Jackson and toward a central issue in the case ? whether Murray was hired by the concert promoter.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-05-18-Jackson-AEG%20Suit-Glance/id-8e819e7684c14562b55dcc1112118bc9

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Sunday, May 19, 2013

Greece to sell Postbank, Proton in July, stress-test big banks

ATHENS (Reuters) - Greece's bank rescue fund will aim to sell Hellenic Postbank and Proton by mid-July with big banks continuing to absorb small lenders as part of plans to revive the battered sector, the country's foreign lenders said in an inspection review.

Greece is recapitalizing its four big banks and winding down others deemed non-viable to improve the sector's capacity to fund the economy out of a deep six-year recession. Banks suffered heavy losses from debt writedowns and bad loans.

Small lenders Hellenic Postbank and Proton were split into "good" and "bad" parts and are now fully owned by the Hellenic Financial Stability Fund (HFSF), a state capital backstop funded with 50 billion euros from the country's bailout package.

The European Union and the International Monetary Fund's review said the 50 billion euro sum is enough to cover recapitalization and resolution costs and would leave enough funds for follow-up stress testing for the sector to be completed by end-2013.

The new tests will assess the adequacy of solvency buffers and loan-loss provisions as banks still face rising credit impairments because of the recession. Bad loans rose to 24.2 percent of their books last year from 16.5 percent in 2011.

The recapitalization of Greece's four core banks - National , Alpha , Piraeus and Eurobank - is expected to be wrapped up by June 14.

The four lenders need 27.5 billion euros to plug capital holes and must raise at least 10 percent from private investors via share offerings to retain management control. The bulk of the funds will be pumped in by the HFSF rescue fund.

The report said entities belonging to the general government cannot buy bank shares in the recapitalization or support third parties with loans, guarantees or subsidies, meaning cash-strapped state pension funds may not take part.

By mid-July authorities will devise a comprehensive strategy to further consolidate the banking sector and privatize banks falling under HFSF control. Any mergers among the four core banks will only be considered after the strategy is defined.

(Reporting by George Georgiopoulos; editing by Keiron Henderson)

Source: http://news.yahoo.com/greece-sell-postbank-proton-july-stress-test-big-122412772.html

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Top 15 Free PR Ideas to Grow Your Online Business

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Source: http://knowfree.net/2013/05/18/top-15-free-pr-ideas-to-grow-your-online-business-22/

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Saturday, May 18, 2013

Jekyll into Hyde: Breathing auto emissions turns HDL cholesterol from 'good' to 'bad'

Jekyll into Hyde: Breathing auto emissions turns HDL cholesterol from 'good' to 'bad'

Friday, May 17, 2013

Academic researchers have found that breathing motor vehicle emissions triggers a change in high-density lipoprotein (HDL) cholesterol, altering its cardiovascular protective qualities so that it actually contributes to clogged arteries.

In addition to changing HDL from "good" to "bad," the inhalation of emissions activates other components of oxidation, the early cell and tissue damage that causes inflammation, leading to hardening of the arteries, according to the research team, which included scientists from UCLA and other institutions.

The findings of this early study, done in mice, are available in the online edition of the journal Arteriosclerosis, Thrombosis and Vascular Biology, a publication of the American Heart Association, and will appear in the journal's June print edition.

Emission particles such as those from vehicles are major pollutants in urban settings. These particles are coated in chemicals that are sensitive to free radicals, which have been known to cause oxidation. The mechanism behind how this leads to atherosclerosis, however, has not been well understood.

In the study, the researchers found that after two weeks of exposure to vehicle emissions, mice showed oxidative damage in the blood and liver ? damage that was not reversed after a subsequent week of receiving filtered air. Altered HDL cholesterol may play a key role in this damaging process, they said.

"This is the first study showing that air pollutants promote the development of dysfunctional, pro-oxidative HDL cholesterol and the activation of an internal oxidation pathway, which may be one of the mechanisms in how air pollution can exacerbate clogged arteries that lead to heart disease and stroke," said senior author Dr. Jesus Araujo, an associate professor of medicine and director of environmental cardiology at the David Geffen School of Medicine at UCLA.

For the study, one group of mice was exposed to vehicle emissions for two weeks and then filtered air for one week, a second was exposed to two weeks of emissions with no filtered air, and a third was exposed to only clean, filtered air for two weeks. This part of the collaborative research took place at the Northlake Exposure Facility at the University of Washington, headed by study author Michael E. Rosenfeld.

"The biggest surprise was finding that after two weeks of exposure to vehicle emissions, one week of breathing clean filtered air was not enough to reverse the damage," said Rosenfeld, a professor of environmental and occupational health sciences and pathology at the University of Washington.

Mice were exposed for a few hours, several days a week, to whole diesel exhaust at a particulate mass concentration within the range of what mine workers usually are exposed to.

After the exposures, UCLA scientists analyzed blood and tissue specimens and checked to see if the protective antioxidant and anti-inflammatory properties of HDL, known as "good" cholesterol, were still intact. They used special analytical laboratory procedures originally developed by study author Mohamad Navab at UCLA to evaluate how "good" or "bad" HDL had become. The team found that many of the positive properties of HDL were markedly altered after the air-pollutant exposure.

For example, the HDL of mice exposed to two weeks of vehicle emissions, including those that received a subsequent week of filtered air, had a much-decreased ability to protect against oxidation and inflammation induced by low-density lipoprotein (LDL) cholesterol, known as "bad" cholesterol, than the mice that had only been exposed to filtered air.

According to researchers, without HDL's ability to inhibit LDL, along with other factors, the oxidation process may run unchecked. Moreover, not only was the HDL of the mice exposed to diesel exhaust unable to protect against oxidation, but, in fact, it further enhanced the oxidative process and even worked in tandem with the LDL to promote even more oxidative damage.

Researchers also found a twofold to threefold increase of additional oxidation products in the blood of mice exposed to vehicle emissions, as well as activation of oxidation pathways in the liver. The degree of HDL dysfunction was correlated with the level of these oxidation markers.

"We suggest that people try to limit their exposure to air pollutants, as they may induce damage that starts during the exposure and continues long after it ends," said first author Fen Yin, a researcher in the division of cardiology at the Geffen School of Medicine.

The current research builds on the team's previous findings that ambient ultrafine particles commonly found in air pollution, including vehicle emissions, enhance the build-up of cholesterol plaques in the arteries and that HDL may play a role.

"Our research helps confirm that the functionality of HDL may be as important to check as the levels," said study author Dr. Alan Fogelman, executive chair of the department of medicine and director of the atherosclerosis research unit at the Geffen School of Medicine.

###

University of California - Los Angeles Health Sciences: http://www.uclahealth.org/

Thanks to University of California - Los Angeles Health Sciences for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/128275/Jekyll_into_Hyde__Breathing_auto_emissions_turns_HDL_cholesterol_from__good__to__bad_

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